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This picture is an example of low MKI: Neuroblastoma (Schwannian stroma-poor), poorly differentiated subtype with a low MKI

Neuroblastoma (Schwannian stroma-poor), poorly differentiated subtype with an intermediate MKI.

Neuroblastoma (Schwannian stroma-poor), poorly differentiated subtype with a high MKI.

A high power view of neuroblastoma with a high MKI. Note numerous karyorrhectic cells and a few mitotic cells. In those tumors with a high MKI, there are usually more karyorrhectic cells than mitotic cells.

In some neuroblastoma tumors, there are cells with a simply hyperchromatic nucleus. Those cell are not included in the MKI counting.

This picture is an example of low MKI: Neuroblastoma (Schwannian stroma-poor), poorly differentiated subtype with a low MKI

MKI

There are 3 MKI classes based on the counting of mitotic cells and cells with nuclear fragmentation: They are low (<100/5,000 cells or <2%), intermediate (100-200/5,000 cells or 2-4%), and high (>200/5,000 cells).


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