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Neuroblastoma (Schwannian stroma-poor), Undifferentiated subtype. Tumor cells, often having one or few prominent nucleoli, are separated by thin fibro-vascular septae.

Neuroblastoma (Schwannian stroma-poor), Undifferentiated subtype. Tumor shows a so-called starry sky appearance.

Neuroblastoma (Schwannian stroma-poor), Undifferentiated subtype. Tumor cells, often having one or few prominent nucleoli, are separated by thin fibro-vascular septae.

Undifferentiated

Primitive tumor, very rare (1~2%) in pNTs, usually requires supplementary techniques (immunohistochemistry, electron microscopy and/or cytogenetics) to establish the diagnosis. Identifiable background of neuropil is absent. Synaptophysin and MAP2 combined are a relatively specific adjunct in helping make this diagnosis.


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