Society for Pediatric Pathology

Journal Watch


Journal Watch

October 2016

SPP Journal Watch – October 2016 was prepared by Dr. Nicoleta Arva, MD/PhD, Pediatric Pathologist, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL.

  1. PAX7 Expression in Rhabdomyosarcoma, Related Soft Tissue Tumors, and Small Round Blue Cell Neoplasms. Charville GW, Varma S, Forgó E, Dumont SN, Zambrano E, Trent JC, Lazar AJ, van de Rijn M. Am J Surg Pathol. 2016 Oct;40(10):1305-15. PMID: 27526298

  2. Assessing the Prognostic Significance of Histologic Response in Osteosarcoma: A Comparison of Outcomes on CCG-782 and INT0133-A Report From the Children's Oncology Group Bone Tumor Committee. Bishop MW, Chang YC, Krailo MD, Meyers PA, Provisor AJ, Schwartz CL, Marina NM, Teot LA, Gebhardt MC, Gorlick R, Janeway KA, Chou AJ. Pediatr Blood Cancer. 2016 Oct;63(10):1737-43. PMID: 27128693

  3. Biomarker development in osteosarcoma-Is there no longer any utility to tumor necrosis? Leavey PJ. Pediatr Blood Cancer. 2016 Oct;63(10):1702-3. PMID: 27349713

  4. A systematic review and meta-analysis of MDM2 polymorphisms in osteosarcoma susceptibility. Bilbao-Aldaiturriaga N, Askaiturrieta Z, Granado-Tajada I, Gori?ar K, Dolžan V, For The Slovenian Osteosarcoma Study Group, Garcia-Miguel P, Garcia de Andoin N, Martin-Guerrero I, Garcia-Orad A. Pediatr Res. 2016 Oct;80(4):472-9. PMID: 27438225

  5. Protein phosphatase 2A Cα regulates proliferation, migration, and metastasis of osteosarcoma cells. Yang D, Okamura H, Morimoto H, Teramachi J, Haneji T. Lab Invest. 2016 Oct;96(10):1050-62. PMID: 27617401

  6. CIC-DUX4 fusion-positive round-cell sarcomas of soft tissue and bone: a single-institution morphological and molecular analysis of seven cases. Gambarotti M, Benini S, Gamberi G, Cocchi S, Palmerini E, Sbaraglia M, Donati D, Picci P, Vanel D, Ferrari S, Righi A, Dei Tos AP. Histopathology. 2016 Oct;69(4):624-34. PMID: 27079694

  7. Oncotargets GD2 and GD3 are highly expressed in sarcomas of children, adolescents, and young adults. Dobrenkov K, Ostrovnaya I, Gu J, Cheung IY, Cheung NK. Pediatr Blood Cancer. 2016 Oct;63(10):1780-5. PMID: 27304202

  8. Inhibition of Bcl-2 family members sensitizes mesenchymal chondrosarcoma to conventional chemotherapy: report on a novel mesenchymal chondrosarcoma cell line. de Jong Y, van Maldegem AM, Marino-Enriquez A, de Jong D, Suijker J, Briaire-de Bruijn IH, Kruisselbrink AB, Cleton-Jansen AM, Szuhai K, Gelderblom H, Fletcher JA, Bovée JV. Lab Invest. 2016 Oct;96(10):1128-37. PMID: 27617402

  9. Reclassification of rhabdoid tumor and pediatric undifferentiated/unclassified sarcoma with complete loss of SMARCB1/INI1 protein expression: three subtypes of rhabdoid tumor according to their histological features. Kohashi K, Tanaka Y, Kishimoto H, Yamamoto H, Yamada Y, Taguchi T, Iwamoto Y, Oda Y. Mod Pathol. 2016 Oct;29(10):1232-42. PMID: 27338635

  10. Recurrent NTRK1 Gene Fusions Define a Novel Subset of Locally Aggressive Lipofibromatosis-like Neural Tumors. Agaram NP, Zhang L, Sung YS, Chen CL, Chung CT, Antonescu CR, Fletcher CD. Am J Surg Pathol. 2016 Oct;40(10):1407-16. PMID: 27259011

  11. "Dissecting Gonadoblastoma" of Scully: A Morphologic Variant That Often Mimics Germinoma. Kao CS, Idrees MT, Young RH, Ulbright TM. Am J Surg Pathol. 2016 Oct;40(10):1417-23. PMID: 27454939

  12. High-level expression of divergent endodermal lineage markers in gonadal and extra-gonadal yolk sac tumors. Shojaei H, Hong H, Redline RW. Mod Pathol. 2016 Oct;29(10):1278-88. PMID: 27443515

  13. WIP1 modulates responsiveness to Sonic Hedgehog signaling in neuronal precursor cells and medulloblastoma. Wen J, Lee J, Malhotra A, Nahta R, Arnold AR, Buss MC, Brown BD, Maier C, Kenney AM, Remke M, Ramaswamy V, Taylor MD, Castellino RC. Oncogene. 2016 Oct 20;35(42):5552-5564. PMID: 27086929

  14. Pediatric Pleomorphic Xanthoastrocytoma Treated With Surgical Resection Alone: Clinicopathologic Features. Dodgshun AJ, Sexton-Oates A, Saffery R, MacGregor D, Sullivan MJ. J Pediatr Hematol Oncol. 2016 Oct;38(7):e202-6. PMID: 27123665

  15. Genome-Wide DNA Methylation Analysis Reveals Epigenetic Dysregulation of MicroRNA-34A in TP53-Associated Cancer Susceptibility. Samuel N, Wilson G, Lemire M, Id Said B, Lou Y, Li W, Merino D, Novokmet A, Tran J, Nichols KE, Finlay JL, Choufani S, Remke M, Ramaswamy V, Cavalli FM, Elser C, Meister L, Taylor MD, Tabori U, Irwin M, Weksberg R, Wasserman JD, Paterson AD, Hansford JR, Achatz MI, Hudson TJ, Malkin D. J Clin Oncol. 2016 Aug 22. pii: JCO676940. PMID: 27551116

  16. Baby genome screening needs more time to gestate. Kaiser J. Science. 2016 Oct 28;354(6311):398-399. PMID: 27789817

  17. Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing. Chen CK, Blanco M, Jackson C, Aznauryan E, Ollikainen N, Surka C, Chow A, Cerase A, McDonel P, Guttman M. Science. 2016 Oct 28;354(6311):468-472. PMID: 27492478

  18. H3K27me3 immunohistochemistry highlights the inactivated X chromosome (Xi) and predicts sex in non-neoplastic tissues. Schaefer IM, Minkovsky A, Hornick JL. Histopathology. 2016 Oct;69(4):702-4. PMID: 27306961

  19. Mutations in GLDN, Encoding Gliomedin, a Critical Component of the Nodes of Ranvier, Are Responsible for Lethal Arthrogryposis. Maluenda J, Manso C, Quevarec L, Vivanti A, Marguet F, Gonzales M, Guimiot F, Petit F, Toutain A, Whalen S, Grigorescu R, Coeslier AD, Gut M, Gut I, Laquerrière A, Devaux J, Melki J. Am J Hum Genet. 2016 Oct 6;99(4):928-933. PMID: 27616481

  20. Bi-allelic Mutations in PKD1L1 Are Associated with Laterality Defects in Humans. Vetrini F, D'Alessandro LC, Akdemir ZC, Braxton A, Azamian MS, Eldomery MK, Miller K, Kois C, Sack V, Shur N, Rijhsinghani A, Chandarana J, Ding Y, Holtzman J, Jhangiani SN, Muzny DM, Gibbs RA, Eng CM, Hanchard NA, Harel T, Rosenfeld JA, Belmont JW, Lupski JR, Yang Y. Am J Hum Genet. 2016 Oct 6;99(4):886-893. PMID: 27616478

  21. Polygenic Causes of Congenital Diaphragmatic Hernia Produce Common Lung Pathologies. Donahoe PK, Longoni M, High FA. Am J Pathol. 2016 Oct;186(10):2532-43. Review. PMID: 27565037

  22. Microarray gene expression analysis in ovine ductus arteriosus during fetal development and birth transition. Goyal R, Goyal D, Longo LD, Clyman RI. Pediatr Res. 2016 Oct;80(4):610-8. PMID: 27356085

  23. Association of genetic polymorphisms around the LIN28B gene and idiopathic central precocious puberty risks among Chinese girls. Hu Z, Chen R, Cai C. Pediatr Res. 2016 Oct;80(4):521-5. PMID: 27304100

  24. Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation. Fujimura KE, Sitarik AR, Havstad S, Lin DL, Levan S, Fadrosh D, Panzer AR, LaMere B, Rackaityte E, Lukacs NW, Wegienka G, Boushey HA, Ownby DR, Zoratti EM, Levin AM, Johnson CC, Lynch SV. Nat Med. 2016 Oct;22(10):1187-1191. PMID: 27618652

  25. Crypt apoptotic body counts in normal ileal biopsies overlap with graft-versus-host disease and acute cellular rejection of small bowel allografts. Sung D, Iuga AC, Kato T, Martinez M, Remotti HE, Lagana SM. Hum Pathol. 2016 Oct;56:89-92. PMID: 27246175

  26. Comparative incidence of rejection occurring in small intestinal and colonic mucosal biopsies of patients undergoing intestinal transplantation. Huard G, Schiano T, Fiel MI, Ward SC, Moon J, Iyer K. Histopathology. 2016 Oct;69(4):600-6. PMID: 27061581

  27. Blockade of interleukin 27 signaling reduces GVHD in mice by augmenting Treg reconstitution and stabilizing FOXP3 expression. Belle L, Agle K, Zhou V, Yin-Yuan C, Komorowski R, Eastwood D, Logan B, Sun J, Ghilardi N, Cua D, Williams CB, Gaignage M, Marillier R, van Snick J, Drobyski WR. Blood. 2016 Aug 3. pii: blood-2016-02-698241. PMID: 27488350

  28. Rosai-Dorfman-type histiocytes occur in eosinophilic chronic rhinosinusitis and potentially play a role in disease initiation and persistence. Wilsher MJ, Bonar F. Histopathology. 2016 Oct;69(4):655-66. PMID: 27061419

  29. Renal epithelial miR-205 expression correlates with disease severity in a mouse model of congenital obstructive nephropathy. Wilhide ME, Feller JD, Li B, Mohamed AZ, Becknell B, Jackson AR, McHugh KM, Ingraham SE. Pediatr Res. 2016 Oct;80(4):602-9. PMID: 27384406

  30. Intrauterine growth restriction impairs right ventricular response to hypoxia in adult male rats. Keenaghan M, Sun L, Wang A, Hyodo E, Homma S, Ten VS. Pediatr Res. 2016 Oct;80(4):547-53. PMID: 27557421

  31. Sudden unexplained early neonatal death or collapse: a national surveillance study. Lutz TL, Elliott EJ, Jeffery HE. Pediatr Res. 2016 Oct;80(4):493-8. PMID: 27384403

  32. Burkitt lymphoma presenting as a mass in the thyroid gland: a clinicopathologic study of 7 cases and review of the literature. Quesada AE, Liu H, Miranda RN, Golardi N, Billah S, Medeiros LJ, Jaso JM. Hum Pathol. 2016 Oct;56:101-8. PMID: 27257042

  33. A study of the mutational landscape of pediatric-type follicular lymphoma and pediatric nodal marginal zone lymphoma. Ozawa MG, Bhaduri A, Chisholm KM, Baker SA, Ma L, Zehnder JL, Luna-Fineman S, Link MP, Merker JD, Arber DA, Ohgami RS. Mod Pathol. 2016 Oct;29(10):1212-20. PMID: 27338637

  34. EBV-negative monomorphic B-cell post-transplant lymphoproliferative disorders are pathologically distinct from EBV-positive cases and frequently contain TP53 mutations. Courville EL, Yohe S, Chou D, Nardi V, Lazaryan A, Thakral B, Nelson AC, Ferry JA, Sohani AR. Mod Pathol. 2016 Oct;29(10):1200-11. PMID: 27443517

  35. Chronic neutrophilic leukemia in a child with a CSF3R T618I germline mutation. Druhan LJ, McMahon DP, Steuerwald N, Price AE, Lance A, Gerber JM, Avalos BR. Blood. 2016 Aug 31. pii: blood-2016-07-730606. PMID: 27581359

  36. A melanin-bleaching methodology for molecular and histopathological analysis of formalin-fixed paraffin-embedded tissue. Chung JY, Choi J, Sears JD, Ylaya K, Perry C, Choi CH, Hong SM, Cho H, Brown KM, Hewitt SM. Lab Invest. 2016 Oct;96(10):1116-27. PMID: 27548802

  37. The Estimation of Intima-Media Thickness and Cardiovascular Risk Factors in Young Survivors of Childhood Cancer. Sadurska E, Brodzisz A, Zaucha-Pra?mo A, Kowalczyk J. J Pediatr Hematol Oncol. 2016 Oct;38(7):549-54. PMID: 26907643

  38. The Association Between Plasma Ferritin Level and Simple Febrile Seizures in Children. Köksal AO, Özdemir O, Büyükkaragöz B, Karaömerlioglu M, Bulus AD. J Pediatr Hematol Oncol. 2016 Oct;38(7):512-6. PMID: 27467370

  39. Cerebrospinal fluid cytokines in the diagnosis of bacterial meningitis in infants. Srinivasan L, Kilpatrick L, Shah SS, Abbasi S, Harris MC. Pediatr Res. 2016 Oct;80(4):566-72. PMID: 27486702

  40. Neonatal NET-inhibitory factor and related peptides inhibit neutrophil extracellular trap formation. Yost CC, Schwertz H, Cody MJ, Wallace JA, Campbell RA, Vieira-de-Abreu A, Araujo CV, Schubert S, Harris ES, Rowley JW, Rondina MT, Fulcher JM, Koening CL, Weyrich AS, Zimmerman GA. J Clin Invest. 2016 Oct 3;126(10):3783-3798. PMID: 27599294

  41. Fetal liver endothelium regulates the seeding of tissue-resident macrophages. Rantakari P, Jäppinen N, Lokka E, Mokkala E, Gerke H, Peuhu E, Ivaska J, Elima K, Auvinen K, Salmi M. Nature. 2016 Oct 12;538(7625):392-396. PMID: 27732581

  42. TET-mediated DNA demethylation controls gastrulation by regulating Lefty-Nodal signalling. Dai HQ, Wang BA, Yang L, Chen JJ, Zhu GC, Sun ML, Ge H, Wang R, Chapman DL, Tang F, Sun X, Xu GL. Nature. 2016 Oct 19;538(7626):528-532. PMID: 27760115