Society for Pediatric Pathology

Atlas Chapters

Neuroblastoma (Schwannian stroma-poor), Poorly differentiated subtype. Neuroblastic cells with indiscernible cytoplasm are separated into incomplete nests by hemorrhagic fibrovascular septa. A few well-define Homer Wright rosettes are seen with central fibrillar processes (neurites) surrounded by cell bodies of the neuroblasts. Inset: A typical rosette formation of Homer Wright type.

Neuroblastoma (Schwannian stroma-poor), Poorly differentiated subtype (high power view). Neuroblastic cells, with no discernible cytoplasm, have a nucleus showing a salt and pepper chromatin pattern and slight variation in size. Tangles of fibrillar processes (neurites) are found without typical rosette formation.

Neuroblastoma (Schwannian stroma-poor), Poorly differentiated subtype. There are poorly developed hemorrhagic fibrovascular septae producing incomplete nesting patterin of the neuroblasti cells. Occasional foci of pale eosinophilic fibrillar material are present without rosette formation.

Poorly Differentiated

This is the most common form, comprising more than 2/3 of pNTs, defined as a tumor composed of neuroblastic cells showing various degrees of differentiation in a background of varying amount of easily recognizable neuropil with no or limited degree of Schwannian development.

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