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Neuroblastoma (Schwannian stroma-poor), Poorly differentiated subtype. Neuroblastoma in a morphologic transition between poorly differentiated subtype and differentiating subtype contains neuroblastic cells with features of early and intermediate stages of differentiation characterized by cytoplasmic enlargement and nuclear enlargement. Those cells usually produce more neurites than undifferentiated neuroblasts. Their nuclei are getting vesicular, and contain one or few small nucleoli. Some cells are multi-nucleated.

Neuroblastoma (Schwannian stroma-poor), borderline of differentiation: Poorly differentiated subtype to Differentiating subtype.

Poorly Differentiated Transition

The first sign of tumor maturation starts with cytoplasmic and nuclear enlargement of the neuroblastic cells. During the process of tumor maturation, vast majority of the neuroblastic cells would undergo apoptosis and disappear (“dropping off”), and a relatively small number of the cells could remain on their way of differentiation towards the differentiating neuroblasts.


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