Atlas Chapters
- Embryology
- Gross Photos
- Undifferentiated
- Poorly Differentiated
- Poorly Differentiated Transition
- Differentiating
- Neuroblastoma Cellularity
- MKI
- Transition to GNB
- GNB - Intermixed
- GNB - Nodular / composite
- Ganglioneuroma - Stroma Dominant
- Common Histologic Features of NB
- Less Common Features in SITU
- Less Common Features - Stage 4S
- Less Common Features - Cystic
- Opsoclonus - Myoclonus
- Regression / Maturation Changes
- Rare Features - Pleomorphic NB
- Rare Features - Spindle Cells
- Rare Features - Other Patterns
- Metastatic Neuroblastoma
- Genetics
- INPC Classification
Regression / Maturation Changes
Regression and maturation changes, as seen in tumors detected through mass screening programs.
Mass screening also detects pNTs with a potential of maturation. Tumor from a patient initially diagnosed as having neuroblastoma through mass screening at 8 months of age, was clinically observed (“watching” without intervention) with repeated MRI tests and urinary catecholamine determinations, and eventually excised at 2 years and 3 months of age. Histology of the tumor shows a typical feature of ganglioneuroblastoma, intermixed, suggesting a process of tumor maturation in its natural history during a course of clinical observation.
Neuroblastoma detected through mass screening. Mass screening often detects pNT cases with a potential of involution/regression. Note a process of remarkable regression (extensive dropping off of neuroblastic cells) of the neuroblastic cells in this case.
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