Symposium on Pediatric Heart Disease

Directors: Rita Alaggio, MD, Ospedale Bambino Gesù, Rome, Italy; Miguel Reyes-Múgica, MD, Children’s Hospital of Pittsburgh of UPMC

At the end of this symposium, participants should be able to:

• List the new approaches to study congenital heart malformations, including imaging and genetic analysis of cilia defects leading to these disorders
• List the findings used to classify cardiac allograft rejection in actionable categories within modern systems
• Enumerate the most important causes of sudden death of cardiac origin

Pediatric Heart Disease Syllabi

The Developmental Etiology and Pathogenesis of HLHS: Insights from Animal Models and Human iPS Cells - Syllabus
Cecilia W. Lo, MD, PhD, University of Pittsburgh School of Medicine

Cardiomyocyte Proliferation in Human Heart Development and Regeneration - Syllabus
Bernhard Kühn, MD, University of Pittsburgh School of Medicine

An Integrated Clinical-Pathologic Approach in Pediatric Cardiac Disease - Syllabi

An Integrated Clinical-Pathologic Approach in Pediatric Cardiac Disease - Presentation

• "How the Clinical Team uses Expertise in Pediatric Pathology for Management and Treatment," Brian Feingold, MD, University of Pittsburgh School of Medicine
• "Interpreting Pediatric Cardiac Transplant Pathology with a Clinical Lens," Jennifer Picarsic, MD, Cincinnati Children’s Hospital

Sudden Death of Cardiovascular Origin in the Young - Syllabus
Marta Cohen, MD, Sheffield Children's Hospital NHS Foundation Trust

COG/SIOP Pathology Update on Liver Tumors Syllabus

COG/SIOP Pathology Update on Liver Tumors - Syllabus
Sarangarajan Ranganathan, MD, Children’s Hospital of Pittsburgh of UPMC

At the end of this presentation, participants should be able to:

• Identify the role of the pathologist as it applies to the current Pediatric Hepatic International Tumor Trial (PHITT) or the COG AHEP1531 study protocol with focus on tissue submission for review and criteria for rapid review
• Describe the significant histologic components of hepatoblastoma and use of immunohistochemistry in distinguishing from hepatocellular neoplasm NOS and hepatocellular carcinoma
• Apply the International Consensus classification of liver tumors to daily practice as it applies to the current COG protocol and identify the science behind the stratification used

Perinatal Symposium: Perinatal Infections

Directors: Mana M. Parast, MD, PhD, University of California San Diego, San Diego Health; Srinivas Rao Annavarapu, MD, Newcastle University, Newcastle upon Tyne, United Kingdom

At the end of this symposium, participants should be able to:

• Distinguish between maternal and fetal response to ascending infections, vs. placental responses to maternal hematogenous infections
• Distinguish between various types of villitis in the placenta, including infectious villitis and villitis of unknown etiology
• Outline novel research on placental mechanisms of viral resistance

Perinatal Infections Syllabi

Maternal Inflammatory Response to Amniotic Fluid Infection - Syllabus
Jane Dahlstrom, MBBS, FPAC, PhD, FRCPA, FFOP, FFSc, Medical School, College of Health and Medicine at the Australian National University

Fetal Inflammatory Response to Amniotic Fluid Infection - Syllabus
Alfons Nadal, MD, Hospital Clínic, University of Barcelona, IDIBAPS, Barcelona, Spain

Spectrum of Villitis in the Placenta - Syllabus
Mana M. Parast, MD, PhD, University of California San Diego Health, San Diego California

Placental Cell Defense Against Viral Infections - Syllabus
Yoel Sadovsky, MD, PhD, Magee-Womens Research Institute