Whether you are a Society for Pediatric Pathology (SPP) member or a visitor, we are glad you came to explore our site. This home page will let you know what is currently going on at the SPP, what has been added to the site, what new Meetings and Events have been listed, and what new Position ads have been recently posted. The Paediatric Pathology Society (PPS) comprises our European colleagues.



What's New
2014 SPP Spring Meeting Evaluations, SAM Post-tests, and CME/SAM Claim forms are still available. Please click here to log in. (Updated 3/2/14)
Latest SPP President's Message is now online. Please click here to read more.
Time to renew your SPP membership! If you haven't done so already, please click here to access.
Perspectives, Volume 28, Insights Into Pediatric Laboratory Medicine, and Volume 29, Soft Tissue Tumors in Children and Adolescents, can now be ordered online direct from Allen Press! Please click here to go to the Allen Press ordering page.




2015 Society for Pediatric Pathology Spring Meeting
March 21-22, 2015
Boston Marriott Copley Place
Boston, MA


Don't miss this opportunity to share your practice
experience and new discoveries with colleagues!

Housing and Transportation Information

ABSTRACT SUBMISSION IS NOW CLOSED

Thank you for submitting your abstracts!




SPP Perinatal Pathology Course
Friday, April 17 - Sunday, April 19, 2015
Chicago, IL


Embassy Suites Downtown/Lakefront
511 N. Columbus Drive
Chicago, IL

Ona M. Faye-Petersen, M.D., Course Director
Linda Ernst, M.D., M.H.S., Assistant Course Director

Course Agenda

Course Objectives

Hotel Information

COURSE REGISTRATION IS NOW OPEN

Please use the Online Registration link below.

Online Registration

Registration will include banquet, syllabi, and interaction with leading experts in the fields of perinatal medicine and perinatal pathology






Prospective new members: Interested in joining the SPP? The New Member online registration feature is currently being upgraded and is temporarily unavailable. Please click here for a PDF Membership Application.

For more information about membership options, please click here

Please note that membership dues are non-refundable






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To learn more about our current fundraiser, please click here








Journal Watch
An eclectic selection of two dozen potentially interesting articles from current journals*

*Click here for the current watch list of journals.

All articles are in print. Please click the PMID number at the end of each citation to see the abstract on PubMed.

DISCLAIMER: Articles are listed in this section for information purposes only. The SPP does not approve or endorse these articles, and the SPP is not responsible for their content.




Holiday 2014 Update
This Journal Watch prepared by Jason A. Jarzembowski, MD, PhD, Children's Hospital of Wisconsin, Milwaukee, WI.

Click here to download the 2014 Journal Watch Holiday Edition.

  • Aslan B, Stemp J, Yip P, Gun-Munro J. Method Precision and Frequent Causes of Errors Observed in Point-of-Care Glucose Testing: A Proficiency Testing Program Perspective. Am J Clin Pathol. 2014 Dec;142(6):857-63. PubMed PMID: 25389340.
  • Rao LK, Gilbertson JR. Longitudinal engagement of pathology residents: a proposed approach for informatics training. Am J Clin Pathol. 2014 Dec;142(6):748-54. PubMed PMID: 25389327.
  • Loh TP, Ranieri E, Metz MP. Derivation of pediatric within-individual biological variation by indirect sampling method: an LMS approach. Am J Clin Pathol. 2014 Nov;142(5):657-63. PubMed PMID: 25319981.
  • Camperlengo L, Shapiro-Mendoza CK, Gibbs F. Improving Sudden Unexplained Infant Death Investigation Practices: An Evaluation of the Centers for Disease Control and Prevention's SUID Investigation Training Academies. Am J Forensic Med Pathol. 2014 Dec;35(4):278-82. PubMed PMID: 25330248.
  • Bakirtzi K, West G, Fiocchi C, Law IK, et al. The Neurotensin-HIF-1α-VEGFα Axis Orchestrates Hypoxia, Colonic Inflammation, and Intestinal Angiogenesis. Am J Pathol. 2014 Dec;184(12):3405-14. PubMed PMID: 25307345.
  • Lubeck BA, Lapinski PE, Bauler TJ, Oliver JA, et al. Blood Vascular Abnormalities in Rasa1(R780Q) Knockin Mice: Implications for the Pathogenesis of Capillary Malformation-Arteriovenous Malformation. Am J Pathol. 2014 Dec;184(12):3163-9. PubMed PMID: 25283357.
  • Banet N, Gown AM, Shih IM, Kay Li Q, et al. GATA-3 Expression in Trophoblastic Tissues: An Immunohistochemical Study of 445 Cases, Including Diagnostic Utility. Am J Surg Pathol. 2014 Sep 3. [Epub ahead of print] PubMed PMID: 25188865.
  • Ma C, Giardiello FM, Montgomery EA. Upper tract juvenile polyps in juvenile polyposis patients: dysplasia and malignancy are associated with foveolar, intestinal, and pyloric differentiation. Am J Surg Pathol. 2014 Dec;38(12):1618-26. PubMed PMID: 25390638.
  • Méhes G, Irsai G, Bedekovics J, Beke L, et al. Activating BRAF V600E Mutation in Aggressive Pediatric Langerhans Cell Histiocytosis: Demonstration by Allele-specific PCR/Direct Sequencing and Immunohistochemistry. Am J Surg Pathol. 2014 Dec;38(12):1644-8. PubMed PMID: 25118810.
  • Linos K, Carter JM, Gardner JM, Folpe AL, et al. Myofibromas with atypical features: expanding the morphologic spectrum of a benign entity. Am J Surg Pathol. 2014 Dec;38(12):1649-54. PubMed PMID: 24921644.
  • Treetipsatit J, Hazard FK. Features of gastric and colonic mucosa in congenital enteropathies: a study in histology and immunohistochemistry. Am J Surg Pathol. 2014 Dec;38(12):1697-706. PubMed PMID: 25007148.
  • La Starza R, Borga C, Barba G, Pierini V, et al. Genetic profile of T-cell acute lymphoblastic leukemias with MYC translocations. Blood. 2014 Dec 4;124(24):3577-82. PubMed PMID: 25270907.
  • Grimwade D, Freeman SD. Defining minimal residual disease in acute myeloid leukemia: which platforms are ready for "prime time"? Blood. 2014 Nov 27;124(23):3345-3355. Epub 2014 Jul 21. Review. PubMed PMID: 25049280.
  • Irving J, Matheson E, Minto L, Blair H, et al. Ras pathway mutations are prevalent in relapsed childhood acute lymphoblastic leukemia and confer sensitivity to MEK inhibition. Blood. 2014 Nov 27;124(23):3420-30. PubMed PMID: 25253770, PubMed Central PMCID: PMC4246039.
  • Heitink-Pollé KM, Nijsten J, Boonacker CW, de Haas M, Bruin MC. Clinical and laboratory predictors of chronic immune thrombocytopenia in children: a systematic review and meta-analysis. Blood. 2014 Nov 20;124(22):3295-307. Epub 2014 Oct 10. PubMed PMID: 25305206.
  • Lee JS, DuBois SG, Boscardin WJ, Wustrack RL, Goldsby RE. Secondary malignant neoplasms among children, adolescents, and young adults with osteosarcoma. Cancer. 2014 Dec 15;120(24):3987-93. PubMed PMID: 25116228.
  • Chipumuro E, Marco E, Christensen CL, Kwiatkowski N, et al. CDK7 Inhibition Suppresses Super-Enhancer-Linked Oncogenic Transcription in MYCN-Driven Cancer. Cell. 2014 Nov 20;159(5):1126-39. PubMed PMID: 25416950, PubMed Central PMCID: PMC4243043.
  • Kao CS, Ulbright TM, Idrees MT. Gonadoblastoma: an immunohistochemical study and comparison to Sertoli cell nodule with intratubular germ cell neoplasia, with pathogenetic implications. Histopathology. 2014 Dec;65(6):861-7. PubMed PMID: 24766183.
  • Adamson SL. sFLT1 in preeclampsia: trophoblast defense against a decidual VEGFA barrage? J Clin Invest. 2014 Nov 3;124(11):4690-2. PubMed PMID: 25329689.
  • Marques Howarth M, Simpson D, Ngok SP, Nieves B, et al. Long noncoding RNA EWSAT1-mediated gene repression facilitates Ewing sarcoma oncogenesis. J Clin Invest. 2014 Dec 1;124(12):5275-90. PubMed PMID: 25401475.
  • Blatt J, Powell CM, Burkhart CN, Stavas J, Aylsworth AS. Genetics of hemangiomas, vascular malformations, and primary lymphedema. J Pediatr Hematol Oncol. 2014 Nov;36(8):587-93. PubMed PMID: 25222064.
  • Baroni LV, Sampor C, Fandiño A, Solernou V, et al. Anterior segment invasion in retinoblastoma: is it a risk factor for extraocular relapse? J Pediatr Hematol Oncol. 2014 Nov;36(8):e509-12. PubMed PMID: 24732059.
  • Hamm JA, Mikhail FM, Hollenbeck D, Farmer M, Robin NH. Incidental detection of cancer predisposition gene copy number variations by array comparative genomic hybridization. J Pediatr. 2014 Nov;165(5):1057-1059.e4. PubMed PMID: 25201531.
  • Dias C, Feng J, Sun H, Shao NY, et al. β-catenin mediates stress resilience through Dicer1/microRNA regulation. Nature. 2014 Dec 4;516(7529):51-5. PubMed PMID: 25383518, PubMed Central PMCID: PMC4257892.
  • Hashizume R, Andor N, Ihara Y, Lerner R, et al. Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma. Nat Med. 2014 Dec;20(12):1394-6. PubMed PMID: 25401693, PubMed Central PMCID: PMC4257862.
  • Zhang J, Li C, Lv L, Yang C, et al. Clinical and experimental study of castleman disease in children. Pediatr Blood Cancer. 2015 Jan;62(1):109-14. PubMed PMID: 25213773.
  • Cohen-Gogo S, Cellier C, Coindre JM, Mosseri V, et al. Ewing-like sarcomas with BCOR-CCNB3 fusion transcript: a clinical, radiological and pathological retrospective study from the Société Française des Cancers de L'Enfant. Pediatr Blood Cancer. 2014 Dec;61(12):2191-8. PubMed PMID: 25176412.
  • Di Rocco M, Andria G, Deodato F, Giona F, et al. Early diagnosis of Gaucher disease in pediatric patients: proposal for a diagnostic algorithm. Pediatr Blood Cancer. 2014 Nov;61(11):1905-9. PubMed PMID: 25131373.
  • Mussa A, Pagliardini S, Pagliardini V, Molinatto C, et al. α-Fetoprotein assay on dried blood spot for hepatoblastoma screening in children with overgrowth-cancer predisposition syndromes. Pediatr Res. 2014 Dec;76(6):544-8. PubMed PMID: 25167201.
  • Holm LL, Rose MV, Kimaro G, Bygbjerg IC, et al. A Comparison of Interferon-γ and IP-10 for the Diagnosis of Tuberculosis. Pediatrics. 2014 Dec;134(6):e1568-75. PubMed PMID: 25422019.



October 2014 Update
This month's Journal Watch prepared by Shelley Caltharp, M.D., Ph.D., Children's Healthcare of Atlanta, Atlanta, GA

Click here to download October 2014 Journal Watch list.

  • Horna P, Zhang L, Sotomayor EM, et al. Diagnostic immunophenotype of acute promyelocytic leukemia before and during early therapy with all-trans retinoic acid. Am J Clin Pathol. 2014 Oct;142(4):546-52. PMID: 25239423.
  • McElroy SJ, Castle SL, Bernard JK, et al. The ErbB4 ligand neuregulin-4 protects against experimental necrotizing enterocolitis. Am J Pathol. 2014 Oct;184(10):2768-78. PMID: 25216938.
  • Martin BA, Kerner JA, Hazard FK, et al. Evaluation of intestinal biopsies for pediatric enteropathy: A proposed immunohistochemical panel approach. Am Journal of Surg Path 2014 Oct;38(10):1387-95. PMID: 25188866.
  • Puls F, Niblett A, Marland G, et al. BCOR-CCNB3 (Ewing-like) sarcoma: A clinicopathologic analysis of 10 cases, in comparison with conventional Ewing sarcoma. Am J Surg Pathol. 2014 Oct;38(10):1307-18. PMID: 24805859.
  • Khoder A, Sarvaria A, Alsuliman A, et al. Regulatory B cells are enriched within the IgM memory and transitional subsets in healthy donors but are deficient in chronic GVHD. Blood. 2014 Sep 25;124(13):2034-45. PMID: 25051962.
  • Musselman JRB, Spector LG, Krailo MD, et al. The Children's Oncology Group Childhood Cancer Research Network (CCRN): Case catchment in the United States. Cancer. 2014 Oct;120(19):3007–15. PMID: 24889136.
  • Yamamoto S, Jaiswal M, Charng WL, et al. A Drosophila genetic resource of mutants to study mechanisms underlying human genetic diseases. Cell. 2014 Sept; 159(1):200–14. PMID: 25259927.
  • Miyoshi K, Kohashi K, Fushimi F, et al. Close correlation between CXCR4 and VEGF expression and frequent CXCR7 expression in rhabdomyosarcoma. Hum Pathol. 2014 Sept;45(9): 1900-9. PMID: 25086956.
  • Bestas B, Moreno PM, Blomberg KE, et al. Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model. J Clin Invest. 2014 Sept;124(9):4067–81. PMID: 25105368.
  • Payne F, Colnaghi R, Rocha N, et al. Hypomorphism in human NSMCE2 linked to primordial dwarfism and insulin resistance. J Clin Invest. 2014 Sept;124(9):4028-38. PMID: 25105364.
  • Richardson RJ, Hammond NL, Coulombe PA, et al. Periderm prevents pathological epithelial adhesions during embryogenesis. J Clin Invest. 2014 Sept;124(9):3891–900. PMID: 25133425.
  • Vo KT, Matthay KK, Neuhaus J, et al. Clinical, biologic, and prognostic differences on the basis of primary tumor site in neuroblastoma: A report from the international neuroblastoma risk group project. J Clin Oncol. 2014 Oct;32(28):3169-76. PMID: 25154816.
  • Ismayilov V, Aksoy DY, Sayinalp N, et al. Increased soluble selectins as a reflection of activated platelets and endothelium in Legg-Calve-Perthes Disease. J Pediatr Hematol Oncol. 2014 Oct;36(7):410-1. PMID: 25000467.
  • Kolandijan NA, Wei C, Burke A, et al. Malignant melanoma in teenagers and young adults. J Pediatr Hematol Oncol. 2014 Oct;36(7):552-8. PMID: 25089601.
  • Wallenstein MB, Arain YH, Birnie KL, et al. Red blood cell transfusion is not associated with necrotizing enterocolitis: A review of consecutive transfusions in a tertiary neonatal intensive care unit . J Pediatr. 2014 Oct;165(4):678-82. PMID: 25039042.
  • Chiu YC, Liao SF, Wu JF, et al. Factors affecting the natural decay of hepatitis B surface antigen in children with chronic hepatitis B virus infection during long-term follow-up J Pediatr. 2014 Oct;165(4):767-72. PMID: 25112693.
  • He X, Zhang L, Chen Y, et al. The G protein α subunit G α s is a tumor suppressor in Sonic hedgehog−driven medulloblastoma. Nature Medicine 20, 1035–1042 (2014) PMID: 25150496.
  • Wein N, Vulin A, Falzarano MS, et al. Translation from a DMD exon 5 IRES results in a functional dystrophin isoform that attenuates dystrophinopathy in humans and mice. Nat Med. 2014 Sep;20(9):992-1000. PMID: 25108525.
  • Madhi SA, Cutland CL, Kuwanda L, et al. Influenza vaccination of pregnant women and protection of their infants. N Engl J Med. 2014 Sep 4;371(10):918-31. PMID: 25184864.
  • Mengelbier LH, Bexell D, Sehic D, et al. Orthotopic Wilms tumor xenografts derived from cell lines reflect limited aspects of tumor morphology and clinical characteristics. Pediatr Blood Cancer. 2014 Nov;61(11):1949–54. PMID: 25044705.
  • Uijterschout L, Swinkels DW, Domellöf M, et al. Serum hepcidin measured by immunochemical and mass-spectrometric methods and their correlation with iron status indicators in healthy children aged 0.5–3 y. Pediatr Res. 2014 Oct;76(4):409-14. PMID: 25116229.
  • Ma X, Barboza LA, Siyahian A, et al. Tetralogy of Fallot: aorto-pulmonary collaterals and pulmonary arteries have distinctly different transcriptomes. Pediatr Res. 2014 Oct;76(4):341–6. PMID: 25000348.
  • Saeed S, Quintin J, Kerstens HH, et al. Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity. Science. 2014 Sep 26;345(6204):1251086. PMID: 25258085.

Click here for previous journal watch listings.




From the Editor's Desk

Dear Colleagues:

Late fall greetings! The SPP 2015 Spring Meeting will be held at the Boston Marriott Copley Place, Boston, MA, on March 21 and 22, 2015. Abstract submission is now open. You can submit your abstract by clicking here. Abstract submission will close on Thursday, November 20, 2014, at 11:59 P.M. Central Time. Housing and transportation information is available by clicking here.

By all accounts the Fall Joint Meeting of PPS and SPP, held September 4 through 6, 2014, at Birmingham UK was very successful. Congratulations to all of the SPP Award winners announced at the meeting. Award winners are listed in the most recent report from Fusun Gundogan of the Distinctions and Awards Committee, which can be viewed by clicking here. If I may, I would like to offer a special tip of the hat to Bahig Shehata for winning the Harry B. Neustein Memorial Award for an unprecedented third time (2008, 2010, and 2014).

Sincerely,
Robert E Ruiz
SPP Website Editor



Questions and comments about website content can be directed to the website editor. Technical concerns can be directed to the site webmaster.









Chief/Director
Pathologist
Fellowship